The extra pounds you gain during the holidays will not only show up on your hips but will also affect your DNA. This is the result of a large-scale international study coordinated by Helmholtz Zentrum München, a partner in the German Center for Diabetes Research, which has now been published in Nature. The study shows that a high BMI leads to epigenetic changes at nearly 200 loci of the genome – with effects on gene expression.

The extra pounds you gain during the holidays will not only show up on your hips but will also affect your DNA. This is the result of a large-scale international study coordinated by Helmholtz Zentrum München, a partner in the German Center for Diabetes Research, which has now been published in Nature. The study shows that a high BMI leads to epigenetic changes at nearly 200 loci of the genome – with effects on gene expression.

Neuherberg, 21. Juni 2016. Wissenschaftler am Helmholtz Zentrum München beschreiben im ‚ Journal of Clinical Investigation‘ einen neuen Wirkstoff, der sehr effizient überschüssiges Kupfer aus Leberzellen bindet.

Neuherberg, 21. Juni 2016. Wissenschaftler am Helmholtz Zentrum München beschreiben im ‚ Journal of Clinical Investigation‘ einen neuen Wirkstoff, der sehr effizient überschüssiges Kupfer aus Leberzellen bindet.

Alzheimer's disease may be 'at work' years ahead of actual symptoms, say IU researchers

Alzheimer's disease may be 'at work' years ahead of actual symptoms, say IU researchers

A research group from Helmholtz Zentrum München has developed an assay whereby mini-breasts in-a-dish can be grown, with cultured human breast epithelial cells rebuilt into the three-dimensional tissue architecture of the mammary gland. For this purpose, a transparent gel is used in which cells divide and spread, similar to the developing mammary gland during puberty. Specifically, cells divide and generate hollow ducts that form a network of branches and terminate in grape-like structures.

Researchers grow mini breast-in-a-dish, provide breakthrough in breast cancer proliferation.

A research group from Helmholtz Zentrum München has developed an assay whereby mini-breasts in-a-dish can be grown, with cultured human breast epithelial cells rebuilt into the three-dimensional tissue architecture of the mammary gland. For this purpose, a transparent gel is used in which cells divide and spread, similar to the developing mammary gland during puberty. Specifically, cells divide and generate hollow ducts that form a network of branches and terminate in grape-like structures.

Researchers at the University Medical Center of Johannes Gutenberg University Mainz (JGU) and the German Research Center for Environmental Health, Helmholtz Zentrum München have discovered that too much of the oncogene Bcl-3 leads to chronic intestinal diseases. They describe in Nature...

Researchers at the University Medical Center of Johannes Gutenberg University Mainz (JGU) and the German Research Center for Environmental Health, Helmholtz Zentrum München have discovered that too much of the oncogene Bcl-3 leads to chronic intestinal diseases. They describe in Nature...

Natural killer cells of the immune system can fend off malignant lymphoma cells and thus are considered a promising therapeutic approach. However, previous studies show that in the direct vicinity of the tumour they lose their effect without a full understanding of this mechanism. Now, researchers of Helmholtz Zentrum München have now elucidated which mechanisms block the natural killer cells and how this blockade could be lifted. The is study is published in the European Journal of…

Researchers identify how lymphoma tumours evade the immune response.

Natural killer cells of the immune system can fend off malignant lymphoma cells and thus are considered a promising therapeutic approach. However, previous studies show that in the direct vicinity of the tumour they lose their effect without a full understanding of this mechanism. Now, researchers of Helmholtz Zentrum München have now elucidated which mechanisms block the natural killer cells and how this blockade could be lifted. The is study is published in the European Journal of…

An international consortium from the TU Dresden and the Helmholtz Zentrum München, together with researchers from Vienna, Bristol and Denver (USA) have successfully completed the first step in development of an insulin vaccine to prevent type 1 diabetes.  As reported by the team in the journal JAMA, evaluations of the international Pre-POINT study point to a positive immune response in persons at risk for the disease who were given oral doses of insulin. Adverse reactions such as…

Researchers complete the first human trials for insulin vaccine to prevent T1 diabetes.

An international consortium from the TU Dresden and the Helmholtz Zentrum München, together with researchers from Vienna, Bristol and Denver (USA) have successfully completed the first step in development of an insulin vaccine to prevent type 1 diabetes. As reported by the team in the journal JAMA, evaluations of the international Pre-POINT study point to a positive immune response in persons at risk for the disease who were given oral doses of insulin. Adverse reactions such as…

Am Helmholtz Zentrum München forscht man zur Zeit unter anderem am kombinierten Einsatz von ‪#‎Biologicals‬ und spezifischer subkutaner Immuntherapie - ein spannendes Interview mit Prof. Schmidt-Weber!

Am Helmholtz Zentrum München forscht man zur Zeit unter anderem am kombinierten Einsatz von ‪#‎Biologicals‬ und spezifischer subkutaner Immuntherapie - ein spannendes Interview mit Prof. Schmidt-Weber!

A small molecule that selectively kills the pathogen causing sleeping sickness and Chagas disease has been developed by scientists from the Helmholtz Zentrum München, along with colleagues from the Technical University of Munich and the Ruhr University Bochum. The researchers first determined the parasite’s Achilles heel by using modern structural biology techniques and then developed an inhibitor with a perfect fit. Prof. Dr. Michael Sattler, Director of the Institute of Structural Biology…

A small molecule that selectively kills the pathogen causing sleeping sickness and Chagas disease has been developed by scientists from the Helmholtz Zentrum München, along with colleagues from the Technical University of Munich and the Ruhr University Bochum. The researchers first determined the parasite’s Achilles heel by using modern structural biology techniques and then developed an inhibitor with a perfect fit. Prof. Dr. Michael Sattler, Director of the Institute of Structural Biology…

#Amyotrophiclateralsclerosis : Researchers including bioinformaticians from the Helmholtz Zentrum München and Ludwig-Maximilians-Universität München organize crowdsourcing challenge to identify new algorithms that will expedite the search for effective therapies for #ALS . In the latest issue of “Nature Biotechnology”, the scientists review the outcome of the crowd-sourcing exercise and describe the most effective algorithms that emerged from it.

#Amyotrophiclateralsclerosis : Researchers including bioinformaticians from the Helmholtz Zentrum München and Ludwig-Maximilians-Universität München organize crowdsourcing challenge to identify new algorithms that will expedite the search for effective therapies for #ALS . In the latest issue of “Nature Biotechnology”, the scientists review the outcome of the crowd-sourcing exercise and describe the most effective algorithms that emerged from it.

Pinterest
Suchen