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ANNA MARIA LUIGIA DI MEDICI
Anna Maria Luisa de' Medici, Electress Palatine (1667-1743) ~ the daughter of Cosimo III and Marguerite Louise d'Orléans. She married John William, Elector Palatine of the Rhine in Düsseldorf in 1691 but returned to Florence in 1717 after his death. She survived her brother Gian Gastone de’ Medici, the last Grand Duke, and remained the only Medici after Tuscany passed to the Duchy of Lorraine in 1737.
Cosimo II (1590-1621) (Grand Duke of Tuscany 1609-1621) was the last Medici to reign over a prosperous Florence before both the territory and family's slow decline in a rapidly changing Europe. Other lasts during his reign include the last to marry a Habsburg consort, the last of offer patronage to someone of the caliber of Galileo, and the last before final closing of the Medici Bank.